Genestra Active Multi Vite 120 Tablets


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Ingredient 1:
Multi Vitamins
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Multi Minerals

Product Overview

Genestra Active Multi Vite- 120 tablets

Advances overall growth and development Assists in the development and maintenance of bones, cartilage, teeth and gums(1) Supports the formation of connective tissue(1) Helps maintain proper muscle, immune function and healthy skin(1) Reduces the risk of neural tube defect when taken prior to becoming pregnant and during early pregnancy(1) Source of vitamin A Helps maintain eyesight, skin and membranes(2) Helps in the development and maintenance of night vision(2) Metabolic enhancer Assists in the absorption of calcium and phosphorus(1) Helps the body metabolize carbohydrates, fats and proteins(1)

PLUS contains folate, Metafolin (L-methylfolate) the active form of folate

Active Multi Vite provides a well-balanced formula in convenient tablet form. A leading factor in the maintenance of good health, Active Multi Vite helps in development and maintenance of bones, cartilage, teeth and gums as well as aids in connective tissue formation and wound healing. Active Multi Vite provides antioxidant support for the maintenance of good health and helps the body metabolize carbohydrates, fats and proteins. The formula assists in maintaining proper muscle, immune function, and healthy skin as well as assists in the formation of red blood cells.(1) Source of vitamin A for the maintenance of good health, to help maintain eyesight, skin, membranes, and immune function. Source of vitamin A in the development and maintenance of night vision, bones and teeth.(2)

References: 1. NHPD Monograph on Multi-vitamin and Mineral. October 2007. 2. NHPD Monograph Beta-Carotene. June 2010.

Additional product info: Aging is accompanied by a variety of physiological, psychological, economic and social changes that compromise nutritional status and/or affect nutritional requirements. For these reasons, the diets of many older adults do not currently meet the recommended intake levels of several essential vitamins and minerals; thus, low micronutrient status is often reported in this population. Nutritional status surveys of the elderly indicate a low to moderate prevalence of frank nutrient deficiencies, but an increased risk of malnutrition, along with evidence of subclinical deficiencies having a direct impact on physiologic function. Overt micronutrient deficiencies have been reported as prevalent in nursing home populations, and recommendations were made that all institutionalized older adults receive a multivitamin/mineral supplement for general nutritional prophylaxis. A clinical study has shown that multivitamin treatment for 8 weeks significantly increased, compared to placebo, plasma concentrations of vitamins D, E, pyridoxal phosphate, folate, B12, C, and improved the riboflavin activity coefficient. Supplementation with a multivitamin formulated at about 100% Daily Value can thus decrease the prevalence of suboptimal vitamin status in older adults and improve their micronutrient status to levels associated with reduced risk for several chronic diseases.(1)

Epidemiological studies have shown that competitors in ultrarnarathon (> 42 km) footraces report a significantly higher incidence of symptoms of upper-respiratory-tract (URT) infections in the immediate postrace period when compared with the incidence among sedentary control subjects during the same time period. A double-blind placebo-controlled study determined whether daily supplementation with 600 mg vitamin C for 21 days before the marathon, would reduce the incidence of symptoms of URT infections after participation in a competitive ultramarathon race. Symptoms of URT infections were monitored for 14 days after the race. Sixty-eight percent of the runners in the placebo group reported the development of symptoms of URT infection after the race; this was significantly more than that reported by the vitamin C-supplemented group (33%). The duration and severity of symptoms of URT infections reported in the vitamin C-supplemented nonrunning control group was also significantly less than in the non-running control group receiving the placebo. This study provides evidence that vitamin C supplementation may enhance resistance to the postrace URT infections that occur commonly in competitive ultramarathon runners and may reduce the severity of such infections in those who are sedentary.(2) Oxidative stress plays an important role in the pathogenesis of cardiovascular disease (CVD). Growing evidence suggest that antioxidant vitamins might reduce the risk of disease outcomes by their ability to scavenge free radicals. A case-control study with vitamin E (400 IU/d) and vitamin C (500 mg/d) supplementation in 40 CVD patients for 2 months showed reduced lipid peroxidation and a strengthened antioxidant defense system. Hence, vitamin E and vitamin C supplementation may have beneficial effects on the heart by reducing oxidative stress in CVD patients.(3) In addition, previous epidemiologic studies suggested an inverse relationship between dietary intake and plasma concentrations of vitamin E and risk of cardiovascular disease. Underpinning the interest in the potential ability of antioxidants to prevent cardiovascular disease is the oxidation hypothesis of atherogenesis. A group of researchers defined the dose-dependent effects of vitamin E (RRR-a-tocopherol) to suppress plasma concentrations of F2-isoprostanes, a biomarker of free radical mediated lipid peroxidation, in participants with polygenic hypercholesterolemia and enhanced oxidative stress, a population at risk for cardiovascular events. A time-course study was first performed in participants supplemented with 3200 I.U./day of vitamin E for 20 weeks. A dose-ranging study was then performed in participants supplemented with 0, 100, 200, 400, 800, 1600, or 3200 I.U./day of vitamin E for 16 weeks. In the time-course study, maximum suppression of plasma F2-Isoprostane concentrations did not occur until 16 weeks of supplementation. In the dose-ranging study there was a linear trend between the dosage of vitamin E and percent reduction in plasma F2-isoprostane concentrations which reached significance at doses of 1600 I.U and 3200 I.U.(4)

A randomized, double-blind, placebo-controlled trial was conducted to determine the effect of 1 year of vitamin E supplementation on respiratory tract infections in elderly nursing home residents. A total of 617 persons aged at least 65 years and who met the studys eligibility criteria were enrolled and Vitamin E (200 IU) or placebo capsule were administered daily. Fewer participants receiving vitamin E acquired 1 or more respiratory tract infections or upper respiratory tract infections. When common colds were analyzed in a post hoc subgroup analysis, the vitamin E group had a lower incidence of common cold and fewer participants in the vitamin E group acquired 1 or more colds. Supplementation with 200 IU per day of vitamin E did not have a statistically significant effect on lower respiratory tract infections in elderly nursing home residents. However, a protective effect of vitamin E supplementation on upper respiratory tract infections, particularly the common cold, was observed.(5)

Vitamin D has complex effects on pulmonary cell biology and immunity with impact on inflammation, host defense, wound healing, repair, and other processes. While the knowledge on direct mechanistic links between Vitamin D and lung diseases is limited, a number of epidemiological and experimental are available that highlight the relevance of this connection.(6) A placebo-controlled, double-blinded study involving 164 young Finnish men provides some evidence for a preventive effect of daily supplementation with 400 IU of vitamin D for 6 months against respiratory tract infection.(7)

Calcium and vitamin D are both essential for the development and maintenance of skeletal health. Calcium plays a vital role in neuromuscular function, many enzyme-mediated processes, blood clotting and in providing rigidity to the skeleton by virtue of its phosphate salts. Over 99% of the bodys calcium is stored in the bone, where, apart from providing mechanical strength, it serves as a mineral reservoir that can be drawn upon to maintain normal plasma calcium. Vitamin D is required to maintain normal blood levels of calcium and phosphate, which are in turn needed for the normal mineralization of bone, muscle contraction, nerve conduction and the general cellular functioning of all body cells. Vitamin D, derived from both endogenous (skin) and exogenous (diet) sources, is converted into 25OHD in the liver and then into 1,25(OH)2D in the kidneys. The latter metabolite controls calcium absorption. However, plasma 25OHD closely reflects vitamin D nutritional status, and because it is the substrate for the renal enzyme that produces 1,25(OH)2D, it could have mainly an indirect and also a direct effect on calcium absorption. A vitamin D shortage would reduce the intestinal absorption of calcium, which could worsen if the diet is deficient of this element. Osteoporosis and its clinical consequence, fragility fractures, are now recognized as major public health problems. Bone mass declines and the risk of fractures increases as people age, especially postmenopausal women. An adequate intake of calcium and vitamin D, including supplementation, has been advocated as a universal primary intervention in the prevention and treatment of high-risk patients. Evidence shows that there is still a high proportion of people with inappropriately low calcium and vitamin D intake and serum levels. For selective groups of people, such as the elderly (frequently older than 70 years), those with low solar exposure and in generally poor or inadequate nutritional condition, guaranteeing a daily intake of at least 1 g of calcium and 700800 IU of vitamin D with supplements would have beneficial effects on bone health. In those individuals with a high risk of osteoporotic fracture, calcium and vitamin D supplements are necessary but frequently insufficient . The Womens Health Initiative (WHI) clinical trial randomly assigned 36,282 postmenopausal women to receive 1000 mg of elemental calcium as calcium carbonate with 400 IU of vitamin D3 daily or placebo for an average follow-up period of 7.0 years. Significantly higher hip bone density but a non-significant reduction (12 percent) in the rate of hip fracture among those assigned to calcium with vitamin D were observed.(9) A recent review discusses vitamin D status and supplementation when treating patients with osteoporosis in relation to risks and prevention of falls and fractures. The authors conclude that poor vitamin D status and low calcium intake are important determinates for osteoporosis and fracture risk. Based on evidence from literature, adequate supplementation with at least 700 IU of vitamin D, preferably cholecalciferol, is required for improving physical function and prevention of falls and fractures. Additional calcium supplementation may be considered when dietary calcium intake is below 700 mg/day, with a supplementation dose that leads to a maximum total daily calcium intake of 1000 to 1200 mg.(10)

Calcium Citrate is a bio-available source of calcium which is the source material of calcium in Active Multi Vite. A randomized crossover study compared the single-dose bioavailability and effects on parathyroid function of two commercially formulated calcium supplements containing 500 mg of elemental calcium. Twenty-five postmenopausal women underwent three phases of study wherein they each took a single dose of calcium citrate with a standard breakfast (as Citracal 250 mg + D), calcium carbonate (as Os-Cal 500 mg + D), or placebo at 8 a.m. Compared with calcium carbonate, calcium citrate provided a 46% greater peak-basal variation and 94% higher change in area under the curve for serum calcium and a 41% greater increment in urinary calcium. Moreover, the decrement in serum parathyroid hormone concentration from baseline was greater after calcium citrate. In conclusion, calcium citrate is more bioavailable than calcium carbonate when given with a meal.(11)

Magnesium (Mg) is the second most abundant intracellular cation in vertebrates. Mg ion is a critical cofactor in more than 300 enzymatic reactions involving energy metabolism, and protein and nucleic acid synthesis. Accordingly, Mg is essential for various normal tissue and organ functions. The primary source of Mg in humans is from the diets. The dietaryMgion is absorbed in the intestine through both active and passive transport systems. Excessive Mg is rapidly excreted into the urine. During Mg deprivation, the kidney avidly conserves Mg and excretes virtually no Mg in the urine. Approximately half of the total Mg in the body of a normal adult human is present intracellularly in soft tissues, and the other half is found in bone, either as exchangeable, surface-bound, divalent cations, which may serve as a reservoir for maintaining normal extracellular Mg level, or as an integral component of the hydroxyapatite lattice in bone matrix, which may be released during bone resorption. Thus, in addition to the intestine and kidney, the bone is involved in Mg homeostasis. Past studies with Mg depletion in both humans and animals indicate that Mg may have key regulatory roles in bone and mineral metabolism. A study examined the effects of daily oral magnesium (Mg) supplementation on bone turnover in 12 young (2736 yr old) healthy men. The study group received orally, for 30 days, 15 mmol Mg (Magnosolv powder, Asta Medica, containing 670 mg magnesium carbonate precipitate (equivalent to 169 mg Mg) and 342 mg magnesium oxide (equivalent to 196 mg)) daily in the early afternoon with 2-h fasting before and after Mg intake. Mg supplementation reduced levels of both serum bone formation and resorption biochemical markers after 15 days, consistent with the premise that Mg supplementation may have a suppressive effect on bone turnover rate. The study concludes that oral Mg supplementation may suppress bone turnover in young adults. Because increased bone turnover has been implicated as a significant etiological factor for bone loss, these findings raise the interesting possibility that oral Mg supplementation may have beneficial effects in reducing bone loss associated with high bone turnover, such as age-related osteoporosis.(12) In another study, twenty postmenopausal women have been divided into two groups. Ten patients were given magnesium citrate (1,830 mg/day) orally for 30 days. Ten postmenopausal women of matching age, menopause duration, and BMI were recruited as the control group and followed without any medication. Thirty consecutive days of oral magnesium supplementation caused significantly decrease in serum iPTH levels in the Mg-supplemented group. Serum osteocalcin levels were significantly increased and urinary deoxypyridinoline levels were decreased in the Mg-supplemented group. This study has demonstrated that oral magnesium supplementation in postmenopausal osteoporotic women suppresses bone turnover. (13)

Magnesium Citrate is a bio-available source of magnesium which is the source material of magnesium in Genestra Brands New Multivitamin. The relative bioavailability of three preparations of Mg (amino-acid chelate, citrate and oxide) were compared at a daily dose of 300 mg of elemental Mg in 46 healthy individuals. The study was a randomized, double-blind, placebo-controlled, parallel intervention, of 60 days duration. Results showed that supplementation of the organic forms of Mg (citrate and amino-acid chelate) showed greater absorption at 60 days than MgO, as assessed by the 24-h urinary Mg excretion. Mg citrate led to the greatest mean serum Mg concentration compared with other treatments following both acute and chronic supplementation. Furthermore, although mean erythrocyte Mg concentration showed no differences among groups, chronic Mg citrate supplementation resulted in the greatest mean salivary Mg concentration compared with all other treatments. Daily supplementation with Mg citrate shows superior bioavailability after 60 days of treatment when compared with the other treatments studied.(14)

The B vitamins folate, vitamin B6 (pyridoxine), and vitamin B12 (cobalamin) are important regulators of homocysteine metabolism in the body, and randomized controlled trials have demonstrated that supplementation with folate alone or in combination with Vitamin B6 and B12 significantly reduce blood homocysteine concentrations.(15) Epidemiological evidence suggests that total plasma homocysteine level is an independent cardiovascular risk factor and may have a potential role with regard to outcome after coronary interventions. Studies on the pathogenesis of homocysteine-induced vascular damage have suggested adverse interaction with vascular smooth muscle cells, endothelium function, plasma lipoproteins, and coagulation cascade. A study provides evidence that homocysteine-lowering therapy with folic acid (1 mg/day), vitamin B12 (cyanocobalamin, 400 ?g/day), and vitamin B6 (pyridoxine hydrochloride, 10 mg/day) for 6 months improves outcome after percutaneous coronary intervention.(16) Beta-carotene at 390-18,000 mcg per day is a source of Vitamin A to help maintain eyesight, skin, membranes and immune function.(17)

Carotenoids are useful oral sun protectants, and supplementation with high doses of beta-carotene protects against UV-induced erythema formation. A study compared the erythema-protective effect of beta-carotene (24 mg/d from an algal source) to that of 24 mg/d of a carotenoid mix consisting of the three main dietary carotenoids, beta-carotene, lutein and lycopene (8 mg/d each). In a placebo-controlled, parallel study design, volunteers with skin type II (n = 12 in each group) received beta-carotene, the carotenoid mix or placebo for 12 weeks. Serum beta-carotene concentration increased three- to four fold in the beta-carotene group, whereas in the mixed carotenoid group, the serum concentration of each of the three carotenoids increased one- to three fold The intake of either beta-carotene or a mixture of carotenoids similarly increased total carotenoids in skin from week 0 to week 12. The intensity of erythema 24 h after irradiation was diminished in both groups that received carotenoids and was significantly lower than baseline after 12 weeks of supplementation.(18) Lutein at up to 20 mg per day and zeaxanthin at up to 2.5 mg per day are antioxidants for the maintenance of eye health, and lutein at 6-20 mg per day and zeaxanthin at 0.7-2.5 mg per day, help to maintain eyesight in conditions (associated with sunlight damage), such as cataracts and age-related macular degeneration, help to reduce the risk of developing cataracts and help to improve macular pigment optical density.(19)

Lycopene, a carotenoid mainly consumed from tomatoes, has a potential beneficial role in patients diagnosed with benign prostate hyperplasia (BPH). A total of 40 patients (aged between 45 and 70 years old) with histologically proven BPH were randomized to receive either lycopene at a dose of 15 mg/day or placebo for 6 months. Symptoms of the disease, as assessed via the International Prostate Symptom Score questionnaire, were improved in both groups with a significantly greater effect in men taking lycopene supplements. In conclusion, this study indicates that lycopene may inhibit disease progression and may ameliorate symptoms in BPH patients.(20) Lycopene not to exceed 30 mg per day provides antioxidants for the maintenance of good health and at 6.5-30 mg per day helps to support prostate health.(21) Adequate zinc status is critical for immune function. Zinc deficiency reduces generation of T cells, depresses humoral and cell-mediated immunity, leads to lymphopenia and thymic atrophy, and increases the frequency and number of infections. A prospective, randomized, controlled clinical trial was conducted involving 231 HIV-infected adults with low plasma zinc levels, who were randomly assigned to receive zinc (12 mg of elemental zinc for women and 15 mg for men) or placebo for 18 months. Zinc supplementation given to HIV-infected adults resulted in a 4-fold decrease in the likelihood of immunological failure, defined as a decrease of CD4+ cell count to <200 cells/mm3, after 18 months of use, compared with placebo. Zinc supplementation also significantly reduced diarrhea, compared with placebo.(22) In a prospective, randomized study design, immunological changes in free-living, healthy aged humans (57-84 years of age) given a placebo, beta-carotene (45 mg/day), selenium (400 ?æg/day) or 45 mg beta-carotene plus 400 mcg selenium per day for 6 months, and after 2 months of discontinuation were evaluated. Selenium and selenium plus beta-carotene supplementation caused an increase in total T cells. The study found that selenium enhanced immune function (NK cell cytotoxicity) and phenotypic expression of T-cell subsets, whereas beta-carotene affected only immune function.(23)

Iodine at 14-800 ?g per day helps in the function of the thyroid gland.(24)

References: 1. McKay DL, Perrone G, Rasmussen H, Dallal G, Hartman W, Cao G, Prior RL, Roubenoff R, Blumberg JB. The effects of a multivitamin/mineral supplement on micronutrient status, antioxidant capacity and cytokine production in healthy older adults consuming a fortified diet. J Am Coll Nutr. 2000 Oct;19(5):613-21. 2. Peters EM, Goetzsche JM, Grobbelaar B, Noakes TD. Vitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runners. Am J Clin Nutr. 1993 Feb;57(2):170-4. 3. Karajibani M, Hashemi M, Montazerifar F, Dikshit M. Effect of vitamin E and C supplements on antioxidant defense system in cardiovascular disease patients in Zahedan, southeast Iran. J Nutr Sci Vitaminol (Tokyo). 2010;56(6):436-40. 4. Roberts LJ 2nd, Oates JA, Linton MF, Fazio S, Meador BP, Gross MD, Shyr Y, Morrow JD. The relationship between dose of vitamin E and suppression of oxidative stress in humans. Free Radic Biol Med. 2007 Nov 15;43(10):1388-93. 5. Meydani SN, Leka LS, Fine BC, Dallal GE, Keusch GT, Singh MF, Hamer DH. Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial. JAMA. 2004 Aug 18;292(7):828-36. 6. Herr C, Greulich T, Koczulla RA, Meyer S, Zakharkina T, Branscheidt M, Eschmann R, Bals R. The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer. Respir Res. 2011 Mar 18;12:31. 7. Laaksi I, Ruohola JP, Mattila V, Auvinen A, Ylikomi T, Pihlajam??ki H. Vitamin D supplementation for the prevention of acute respiratory tract infection: a randomized, double-blinded trial among young Finnish men. J Infect Dis. 2010 Sep 1;202(5):809-14. 8. D??az-L??pez B, Cannata-And??a JB. Supplementation of vitamin D and calcium advantages and risks. Nephrol Dial Transplant. 2006 Sep;21(9):2375-7. 9. Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, Lewis CE, Bassford T, Beresford SA, Black HR, Blanchette P, Bonds DE, Brunner RL, Brzyski RG, Caan B, Cauley JA, Chlebowski RT, Cummings SR, Granek I, Hays J, Heiss G, Hendrix SL, Howard BV, Hsia J, Hubbell FA, Johnson KC, Judd H, Kotchen JM, Kuller LH, Langer RD, Lasser NL, Limacher MC, Ludlam S, Manson JE, Margolis KL, McGowan J, Ockene JK, O'Sullivan MJ, Phillips L, Prentice RL, Sarto GE, Stefanick ML, Van Horn L, Wactawski-Wende J, Whitlock E, Anderson GL, Assaf AR, Barad D; Women's Health Initiative Investigators. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med. 2006 Feb 16;354(7):669-83. 10. van den Bergh JP, Bours SP, van Geel TA, Geusens PP. Optimal use of vitamin D when treating osteoporosis. Curr Osteoporos Rep. 2011 Mar;9(1):36-42. 11. Heller HJ, Greer LG, Haynes SD, Poindexter JR, Pak CY. Pharmacokinetic and pharmacodynamic comparison of two calcium supplements in postmenopausal women. J Clin Pharmacol. 2000 Nov;40(11):1237-44. 12. Dimai HP, Porta S, Wirnsberger G, Lindschinger M, Pamperl I, Dobnig H, Wilders-Truschnig M, Lau KH. Daily oral magnesium supplementation suppresses bone turnover in young adult males. J Clin Endocrinol Metab. 1998 Aug;83(8):2742-8. 13. Aydin H, Deyneli O, Yavuz D, G??z?¬ H, Mutlu N, Kaygusuz I, Akalin S. Short-term oral magnesium supplementation suppresses bone turnover in postmenopausal osteoporotic women. Biol Trace Elem Res. 2010 Feb;133(2):136-43. 14. Walker AF, Marakis G, Christie S, Byng M. Mg citrate found more bioavailable than other Mg preparations in a randomised, double-blind study. Magnes Res. 2003 Sep;16(3):183-91. 15. Larsson SC, M??nnist?? S, Virtanen MJ, Kontto J, Albanes D, Virtamo J. Folate, vitamin B6, vitamin B12, and methionine intakes and risk of stroke subtypes in male smokers. Am J Epidemiol. 2008 Apr 15;167(8):954-61. 16. Schnyder G, Roffi M, Flammer Y, Pin R, Hess OM. Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial. JAMA. 2002 Aug 28;288(8):973-9. 17. NHPD Monograph Beta-Carotene. June 2010. 18. Heinrich U, G??rtner C, Wiebusch M, Eichler O, Sies H, Tronnier H, Stahl W. Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema. J Nutr. 2003 Jan;133(1):98-101. 19. NHPD Monograph on Marigold Extract and Isolates (Lutein and Zeaxanthin). August 2011. 20. Schwarz S, Oberm?¬ller-Jevic UC, Hellmis E, Koch W, Jacobi G, Biesalski HK. Lycopene inhibits disease progression in patients with benign prostate hyperplasia. J Nutr. 2008 Jan;138(1):49-53. 21. NHPD AbLS on Lycopene. September 2009. 22. Baum MK, Lai S, Sales S, Page JB, Campa A. Randomized, controlled clinical trial of zinc supplementation to prevent immunological failure in HIV-infected adults. Clin Infect Dis. 2010 Jun 15;50(12):1653-60. 23. Wood SM, Beckham1 C, Yosioka2 A, Darban3 H, Watson RR. beta-Carotene and selenium supplementation enhances immune response in aged humans. Integr Med. 2000 Mar 21;2(2):85-92. 24. NHPD Monograph on Multi-vitamin and Mineral. October 2007.


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