Genestra Calcium 90 Capsules

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sub Category:
Bone Support
MPN:
04219-90U
Type of delivery:
Capsule
Ingredient 1:
Calcium

Product Overview

 

Genestra Calcium- 90 Capsules

 

• Single mineral calcium supplementation in vegetable capsules • 150 mg Calcium per capsule • Ideal for vegans • Convenient capsule format increases patient compliance

Calcium aspartate provides an excellent source of this mineral to help in the development and maintenance of bones and teeth, especially in childhood, adolescence and young adulthood. Calcium intake, when combined with sufficient vitamin D, a healthy diet, and regular exercise, may reduce the risk of developing osteoporosis (1). The capsules are 100% vegetable-sourced.

 

Additional product info: Calcium and the vitamin D hormonal system are both essential for the development and maintenance of skeletal health. Calcium plays a vital role in neuromuscular function, many enzyme-mediated processes, blood clotting and in providing rigidity to the skeleton by virtue of its phosphate salts. Over 99% of the body’s calcium is stored in the bone, where, apart from providing mechanical strength, it serves as a mineral reservoir that can be drawn upon to maintain normal plasma calcium. Vitamin D is required to maintain normal blood levels of calcium and phosphate, which are in turn needed for the normal mineralization of bone, muscle contraction, nerve conduction and the general cellular functioning of all body cells. Vitamin D, derived from both endogenous (skin) and exogenous (diet) sources, is converted into 25OHD in the liver and then into 1,25(OH)2D in the kidneys. The latter metabolite controls calcium absorption. However, plasma 25OHD closely reflects vitamin D nutritional status, and because it is the substrate for the renal enzyme that produces 1,25(OH)2D, it could have mainly an indirect and also a direct effect on calcium absorption. A vitamin D shortage would reduce the intestinal absorption of calcium, which could worsen if the diet is deficient of this element. Osteoporosis and its clinical consequence, fragility fractures, are now recognized as major public health problems. Bone mass declines and the risk of fractures increases as people age, especially postmenopausal women. An adequate intake of calcium and vitamin D, including supplementation, has been advocated as a universal primary intervention in the prevention and treatment of high-risk patients. Evidence shows that there is still a high proportion of people with inappropriately low calcium and vitamin D intake and serum levels. For selective groups of people, such as the elderly (frequently older than 70 years), those with low solar exposure and in generally poor or inadequate nutritional condition, guaranteeing a daily intake of at least 1 g of calcium and 700–800 IU of vitamin D with supplements would have beneficial effects on bone health. In those individuals with a high risk of osteoporotic fracture, calcium and vitamin D supplements are necessary but frequently insufficient (2). The Women’s Health Initiative (WHI) clinical trial randomly assigned 36,282 postmenopausal women to receive 1000 mg of elemental calcium as calcium carbonate with 400 IU of vitamin D3 daily or placebo for an average follow-up period of 7.0 years. Significantly higher hip bone density but a non-significant reduction (12 percent) in the rate of hip fracture among those assigned to calcium with vitamin D were observed (3). A recent review discusses vitamin D status and supplementation when treating patients with osteoporosis in relation to risks and prevention of falls and fractures. The authors conclude that poor vitamin D status and low calcium intake are important determinates for osteoporosis and fracture risk. Based on evidence from literature, adequate supplementation with at least 700 IU of vitamin D, preferably cholecalciferol, is required for improving physical function and prevention of falls and fractures. Additional calcium supplementation may be considered when dietary calcium intake is below 700 mg/day, with a supplementation dose that leads to a maximum total daily calcium intake of 1000 to 1200 mg (4).

Calcium Aspartate is a bio-available soluble complex of Calcium l-Aspartic acid which is the source material of calcium in Genestra Brands TM. Calcium Aspartate has been used as a source of calcium in an open-label, calcium-controlled study to evaluate the effect of alfacalcidol on bone turnover in elderly women with osteoporosis. A total of 80 patients were divided into two groups: the control group, in which patients were given calcium aspartate at a dose of 78 mg/day and alfacalcidol group in which patients were given alfacalcidol 1 mcg/day together with the same dose of calcium aspartate for 6 months. The evaluation of calcium metabolism before and after the administration of calcium or alfacalcidol plus calcium, serum levels of calcium were measured in both groups. Bone resorption markers in control groups were maintained at the baseline value, whereas these values decreased in alfacalcidol group by 15% (5). A multicenter, double-placebo, double-blind study to verify the effects of calcium aspartate anhydrous on osteoporosis was performed on a total of 1,306 patients. Group I receives CaAA (4 grams per day, 520 mg elemental) and a placebo matching Vitamin D. Group II receives calcium citrate (1,500 mg elemental per day) and Vitamin D (1,000 IU per day). Group III was given one placebo matching calcium, and another placebo matching Vitamin D. The intervention duration was for 12 months. Calcium aspartate increases bone mineral density significantly in 3-12 months (6).

 

Other ingredients: hypromellose, magnesium stearate, silica, microcrystalline cellulose

 

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