Genestra Cranberry Plus 90 Vegetable Capsules

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sub Category:
Urinary Support
MPN:
10560-90U
Type of delivery:
Capsule
Ingredient 1:
Cranberry fruit extract
Ingredient 2:
Vitamin C

Product Overview

Genestra Cranberry Plus- 90 capsules

 

• Cranberry in combination with Vitamin C • Helps prevent recurrent urinary tract infections (1). • Convenient softgel format • Increases patient compliance • Cranberry Plus provides this well-known ingredient recognized for its ability to assist in the management of urinary tract infections. An antioxidant for the maintenance of good health (2).

 

Additional product info: Cranberry fruit at 10-30 grams per day is traditionally used in Herbal Medicine to help prevent urinary tract infections (UTIs) and to provide antioxidants for the maintenance of good health (3). A study was performed to determine, from a societal perspective, the effectiveness and cost effectiveness of concentrated cranberry tablets, versus cranberry juice, versus placebo used as prophylaxis against lower urinary tract infection (UTI) in adult women. One hundred fifty sexually active women aged 21 through 72 years were randomized for one year to one of three groups of prophylaxis: placebo juice + placebo tablets versus placebo juice + cranberry tablets, versus cranberry juice + placebo tablets. Tablets were taken twice daily, juice 250 ml three times daily ; one tablet of concentrated cranberry juice was at least 1:30 parts concentrated juice. Both cranberry juice and cranberry tablets statistically significantly decreased the number of patients experiencing at least 1 symptomatic UTI/year compared with placebo. Total antibiotic consumption was less annually in both treatment groups compared with placebo (4). In an open label pilot study, women took one capsule twice daily for 12 weeks containing 200 mg of a concentrated cranberry extract standardized to 30% phenolics (25% minimum proanthocyanidins). All 12 subjects participated in the 12-week study and were available for follow up 2 years later. Cranberry preparation with a high phenolic content may completely prevent UTIs in women who are subject to recurrent infections (5).

Lower urinary tract symptoms (LUTS) are a common condition in older men. The objective of the a study was to evaluate the efficacy and tolerability of cranberry (Vaccinium macrocarpon) powder in men at risk of prostate disease with LUTS, elevated prostate-specific antigen (PSA), negative prostate biopsy and clinically confirmed chronic non-bacterial prostatitis. Forty-two participants received either 1500 mg of the cranberry fruit powder per day for 6 months (cranberry group; n 21) or no cranberry treatment (control group; n 21). In contrast to the control group, patients in the cranberry group had statistically significant improvement in International Prostate Symptom Score, QoL, urination parameters including voiding parameters (rate of urine flow, average flow, total volume and post-void residual urine volume), and lower total PSA level on day 180 of the study. The results of the trial are the first firm evidence that cranberries may ameliorate LUTS, independent of benign prostatic hyperplasia or C-reactive protein level (6).

Cranberry constituents are known to exert anti-adhesion activity on H. pylori in vitro. To determine their possible additive effect to triple therapy with omeprazole, amoxicillin and clarithromycin (OAC), a double-blind randomized clinical study was carried out. One-hundred-seventy-seven patients with H. pylori infection treated with OAC for 1 week were randomly allocated to receive 250 mL of either cranberry juice (cranberry-OAC, n = 89) or placebo beverage (placebo-OAC, n = 88) twice daily and only cranberry juice or placebo beverage for the next 2 weeks. Analysis by gender revealed that for female subjects, the eradication rate was higher in the cranberry-OAC arm than in the placebo-OAC arm and significantly higher than in the non-placebo-OAC group. These results suggest that the addition of cranberry to triple therapy improves the rate of H. pylori eradication in females (7). A prospective, randomized, double-blind, placebo-controlled trial was conducted, where 189 adults aged 48.9 +/- 11.2 years with H. pylori infection were randomly divided into two groups: cranberry juice (n = 97) and placebo (n = 92). Participants were assigned to orally receive two 250-ml juice boxes of cranberry juice or matching placebo beverage daily for 90 days. After 90 days, the study concluded that 14 of the 97 subjects in the cranberry juice treatment group versus 5 of the 92 in the placebo group yielded negative test results. Eleven individuals from the cranberry juice treatment group and only two from the placebo group were negative at 35 and 90 days of experiment. These results were significant. Regular consumption of cranberry juice can suppress H. pylori infection in endemically afflicted populations (8). The aim of a study was to determine whether consumption of sweetened dried cranberries elicits urinary anti-adherence properties against Escherichia coli as previously demonstrated with cranberry juice and/or sweetened cranberry juice cocktail, compared to unsweetened raisins. Uropathogenic E. coli isolates were obtained from five women with culture-confirmed urinary tract infections (UTIs). Four urine samples were collected from each subject. The first urine sample was collected before any study intervention. The second urine sample was collected 2-5 hours after consumption of one box (42.5 g) of raisins. The third urine sample was collected 5-7 days later. The final urine sample was collected 2-5 hours after consumption of approximately 42.5 g of dried cranberries. Data from this pilot study on only five subjects suggest that consumption of a single serving of sweetened dried cranberries may elicit bacterial antiadhesion activity in human urine (9).

Cranberries, high in polyphenols, have been associated with several cardiovascular health benefits, although limited clinical trials have been reported to validate these findings. A study tested the hypothesis that commercially available low-energy cranberry juice will decrease lipid oxidation, inflammation, and dyslipidemia, in subjects with metabolic syndrome. In a randomized, double-blind, placebo-controlled trial, participants identified with metabolic syndrome (n = 15-16/group) were assigned to 1 of 2 groups: cranberry juice (480 mL/day) or placebo (480 mL/day) for 8 weeks. Cranberry juice significantly increased plasma antioxidant capacity and decreased oxidized low-density lipoprotein and malondialdehyde. In conclusion, low-energy cranberry juice (2 cups/day) significantly reduces lipid oxidation and increases plasma antioxidant capacity in women with metabolic syndrome (10).

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