Product Overview
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Genestra Glutathione Precursors- 30 capsules
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N-acetyl-L-cysteine, alpha lipoic acid, glutamic acid and glycine formulation As a source of antioxidants for the maintenance of good health (1) Convenient vegetable capsule format Increases patient compliance
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Additional product info: The effect of N-acetylcysteine (NAC) supplementation on parameters of oxidative damage and inflammatory response after high-intensity eccentric exercise (EE) were evaluated. 29 participants were randomly selected to receive either placebo, NAC supplementation (10 mg/kg body weight per day) or NAC plus placebo. Results showed a significant increase in muscle soreness in all the groups on the 2nd day after EE and a decrease in the following days. A significant increase was observed in malondialdehyde and carbonyl levels on the 4th and 7th days after EE in all groups. TNF-? increased significantly on the 2nd day after eccentric exercise and decreased in the following days irrespective of NAC supplementation; concentration of IL-10 increased significantly on the 4th day in all groups. Only the supplemented groups maintained high levels of IL-10 on the 7th day after EE. The results suggest that treatment with NAC represents an important factor in the defense against muscle soreness and has different effects on oxidative damage and pro- and anti-inflammatory cytokines (3).
Oxygen-sensing chemoreceptors contribute significantly to the regulation of the respiratory drive and arterial PO2 levels. The hypoxic ventilatory response (HVR) decreases strongly with age and is modulated by prolonged hypoxia and physical exercise. Several earlier studies indicated that the regulation of the ventilatory response and erythropoietin (EPO) production by the respective oxygen sensors involves redox-sensitive signaling pathways, which are triggered by the O2-dependent production of reactive oxygen species. The hypothesis that HVR and EPO production are modulated by thiol compounds or changes in the plasma thiol-disulfide redox state (REDST) was investigated. Subjects received 200 mg of NAC, three times a day, or a placebo for 5 days. It was demonstrated that both responses are enhanced and that HVR is correlated with plasma thiol level and REDST. Results suggest the possibility that age-related changes in plasma REDST may account for the age-related changes in HVR (4).
Forced Expiratory Volume in one second (FEV1) is used for the classification of disease severity. However, it is a poor predictor of clinical symptoms, exercise tolerance, and response to bronchodilators. Progressive reduction in inspiratory capacity (IC) during exercise reflects dynamic hyperinflation and is a good predictor of decreased exercise ability as well as increased exertional dyspnea. A study examined the effect of 1,200 mg/d of NAC on lung hyperinflation at rest and after exercise. IC and Forced Vital Capacity (FVC) were higher especially after exercise after NAC treatment compared with placebo treatment. In addition, the relationship of residual volume to total lung capacity was reduced in a similar pattern. Furthermore, endurance time was longer after NAC treatment compared with placebo treatment. NAC treatment of patients has a beneficial effect on physical performance, probably due to a reduction in air trapping (5).
Alpha Lipoic Acid, not to exceed 600 mg per day, provides antioxidants for the maintenance of good health, and at 600 mg per day, helps promote healthy glucose metabolism (6). The aim of a study was to assess the effect of oral supplementation with LA alone and in combination with alpha-tocopherol (AT) on measures of oxidative stress. A total of 31 healthy adults were supplemented for 2 months either with LA (600 mg/day), or with AT (400 IU/day) alone, and then with the combination of both for 2 additional months. LA significantly increased the lag time of low-density lipoprotein (LDL) lipid peroxide formation for both copper-catalyzed and 2,2-azobis (2-amidinopropane) hydrochloride (AAPH)-induced LDL oxidation, decreased urinary F2-isoprostanes levels, and plasma carbonyl levels after AAPH oxidation. In conclusion, LA supplementation functions as an antioxidant, because it decreases plasma- and LDL-oxidation and urinary isoprostanes (7).
The metabolic syndrome is associated with increased angiotensin II activity, induction of a proinflammatory and oxidative state, and endothelial dysfunction. The ability of irbesartan, an angiotensin receptor blocker, and lipoic acid, an antioxidant, on endothelial function and inflammation was evaluated in patients with the metabolic syndrome. 58 subjects with the metabolic syndrome were randomized in a double-blinded manner to irbesartan 150 mg/d, lipoic acid 300 mg/d, both irbesartan and lipoic acid, or matching placebo for 4 weeks. After 4 weeks of therapy, endothelium-dependent flow-mediated vasodilation of the brachial artery was increased in the irbesartan, lipoic acid, and irbesartan plus lipoic acid groups, compared with the placebo group. Treatment with irbesartan and/or lipoic acid was associated with statistically significant reductions in plasma levels of interleukin-6 and plasminogen activator-1. Administration of irbesartan and/or lipoic acid to patients with the metabolic syndrome improves endothelial function and reduces proinflammatory markers (8).
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Other ingredients: Hypromellose, vegetable magnesium stearate
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