Genestra TIM Immune Forte- 60 tablets
• Multivitamins, zinc and glandular formulation in tablets • Helps to maintain eyesight, skin, membranes and immune function (1) • Convenient tablet format • Increases patient compliance • With added bee pollen • 25 mg per tablet
TIM provides vitamins and synergistic nutrients along with glandular tissues, formulated specifically to support and maintain a healthy immune system. TIM also helps in connective tissue formation, to maintain healthy skin and in wound healing.
References: 1 NHPD Monograph on Multi-Vitamin and Mineral. October 2007.
Additional product info: Adequate zinc status is critical for immune function. Zinc deficiency reduces generation of T cells, depresses humoral and cell-mediated immunity, leads to lymphopenia, and increases the frequency and number of infections (2). A prospective, randomized, controlled clinical trial was conducted involving 231 HIV-infected adults with low plasma zinc levels, who were randomly assigned to receive zinc (12 mg of elemental zinc for women and 15 mg for men) or placebo for 18 months. Zinc supplementation given to HIV-infected adults resulted in a 4-fold decrease in the likelihood of immunological failure, defined as a decrease of CD4+ cell count to <200 cells/mm3, after 18 months of use, compared with placebo. Zinc supplementation also significantly reduced diarrhea, compared with placebo (3). Zinc aspartate is source material of zinc in Genestra Brands TM TIM. In a clinical trial, 300 mg of zinc aspartate (equal to 60 mg elemental zinc per day) was administered to 14 patients with inactive to moderately active inflammatory bowel disease for 4 weeks in order to evaluate the effect of oral zinc supplementation on metallothionein and superoxide dismutase levels in these patients. The plasma zinc concentration of these patients was significantly lower at the start of the study when compared to that of 22 healthy controls, but increased significantly towards the levels of controls during the supplementation period (4).
Over the last several decades, vitamin A has been used in the treatment of various skin conditions. During the past 20 years, retinoids including retinol, retinyl palmitate, all-trans, 13-cis-, and 9-cis-retinoic acid (RA) have been evaluated in several trials. The retinoids have been evaluated due to their role in cellular differentiation. Although numerous studies indicate that treatment with RA is effective, this strategy is severely limited for long-term use by reported adverse events and its teratogenic potential. An alternative retinoid approach is to develop a method of increasing endogenous concentrations of RA, as the biological activity of retinoids is obtained through their conversion to RA. An investigation was conducted to determine whether vitamin A (retinyl palmitate) supplementation at 25,000, 50,000, or 75,000 IU against a placebo significantly increases circulating RA concentrations of all-trans-, 9-cis-, and 13-cis-RA. The results of the study suggests that supplementation with retinyl palmitate is an effective means to increase circulating all-trans, 9-cis-, and 13-cis-RA concentrations among humans (5). The relationship between the concentrations of micronutrients in the plasma and in the target tissues has not been established. To gain information on tissue micronutrient concentration and its relationship to the plasma level, paired skin and plasma samples from 93 patients were obtained. These subjects were randomly assigned and received placebo or retinol (25,000 lU/day) intervention for 48 to 65 months as part of an on-going study. The retinol supplementation caused a significant increase in the concentration of retinol and retinyl palmitate in the plasma and skin (target tissue) (6). Another study showed that retinol palmitate at 10,000 IU by mouth for 90 days significantly reduced rectal symptoms of radiation proctopathy, perhaps because of wound-healing effects (7).
Corneal haze and myopic regression are the main undesirable complications after excimer laser treatment. In the past few years, several authors indicated that keratocytes and epithelial cells are mainly involved in the healing response. In particular, it was suggested that the disappearance of anterior stromal keratocytes in response to excimer laser surgery was an initiating factor, which could lead to epithelial hyperplasia and eventually to haze formation and regression. Vitamin A exerts a moderate antioxidant activity and plays an essential part in epithelial growth and limbal stem cell differentiation, promoting corneal wound healing. As slower tissue regeneration causes an increased risk of accumulation of oxidant-inflicted damage in the tissue components, corneal re-epithelialisation time is crucial. A randomized, double masked clinical trial has been performed to evaluate the effect of a high dose vitamin A and E supplementation on corneal re-epithelialisation time, visual acuity and haze following photorefractive keratectomy (PRK). In this study, the results showed that vitamins A (25 000 IU retinol palmitate) and E (230 mg alpha-tocopheryl nicotinate) for 3 months post PRK significantly decreased re-epithelialisation time, haze formation, and myopic regression occurrence (8).
The thymus gland is related to the thyroid gland (9). The advantage of using thymus over thyroid substance is that the improvement is found without the adverse effects of thyroid, such as palpitation and weight loss (10).
Shaw cites a study by Mikulicz conducted in 1895 in which thymus substance was first used to treat simple goitre. This study involved treating 11 cases of simple goitre, of which 5 cases were favourably influenced, with improvement of dyspnoea (shortness of breath) and decreased circumference of the neck. Mikulicz also noted positive results following the treatment of two cases of Grave’s Disease by using thymus gland, although no conclusions were drawn from these cases (11).
Shaw notes that the thymus appears in the third month of foetal life, at which time leukocytes are first observed, lending support that the thymus gives rise to leukocytes (12). Harrower specifically suggests the thymus has an effect upon the production and character of the blood and has been recommended for years as a leukocytogenetic (13).
12 to 20 tabloids (tablets) of 0.5 - 1 g of dry thymus substance may be given daily (6 - 20 g/day) (14).
Attributes of TIM covered by the NHPD Monographs: Helps the body to metabolize carbohydrates, fats and proteins. Helps in connective tissue formation and to maintain healthy skin. Helps to maintain eyesight, skin, membranes and immune function. Helps in the development and maintenance of night vision. Helps in the development and maintenance of bones, cartilage, teeth and gums. Helps in wound healing. An antioxidant for the maintenance of good health. Helps to prevent vitamin A, vitamin C and vitamin E deficiency.
References: 2 Baum MK, Lai S, Sales S, Page JB, Campa A. Randomized, controlled clinical trial of zinc supplementation to prevent immunological failure in HIV-infected adults. Clin Infect Dis. 2010 Jun 15;50(12):1653-60. Abstract; Page 1653, 1st paragraph;Page 1657, Discussion, 1st paragraph; Page 1658, Conclusion 3 Baum MK, Lai S, Sales S, Page JB, Campa A. Randomized, controlled clinical trial of zinc supplementation to prevent immunological failure in HIV-infected adults. Clin Infect Dis. 2010 Jun 15;50(12):1653-60. Abstract; Page 1653, 1st paragraph;Page 1657, Discussion, 1st paragraph; Page 1658, Conclusion 4 Mulder TP, van der Sluys Veer A, Verspaget HW, Griffioen G, Peña AS, Janssens AR, Lamers CB. Effect of oral zinc supplementation on metallothionein and superoxide dismutase concentrations in patients with inflammatory bowel disease. J Gastroenterol Hepatol. 1994 Sep-Oct;9(5):472-7. Abstract 5 Sedjo RL, Ranger-Moore J, Foote J, Craft NE, Alberts DS, Xu MJ, Giuliano AR. Circulating endogenous retinoic acid concentrations among participants enrolled in a randomized placebo-controlled clinical trial of retinyl palmitate. Cancer Epidemiol Biomarkers Prev. 2004 Nov;13(11 Pt 1):1687-92. Abstract; Page 1687, Introduction, 1st & 2nd paragraphs; Page 1691, Conclusion 6 Peng YM, Peng YS, Lin Y, Moon T, Baier M. Micronutrient concentrations in paired skin and plasma of patients with actinic keratoses: effect of prolonged retinol supplementation. Cancer Epidemiol Biomarkers Prev. 1993 Mar-Apr;2(2):145-50. Abstract; Page 145, Introduction, 2nd paragraph; Page 150, Conclusion 7 Ehrenpreis ED, Jani A, Levitsky J, Ahn J, Hong J. A prospective, randomized, double-blind, placebo-controlled trial of retinol palmitate (vitamin A) for symptomatic chronic radiation proctopathy. Dis Colon Rectum. 2005 Jan;48(1):1-8. Abstract 8 Vetrugno M, Maino A, Cardia G, Quaranta GM, Cardia L. A randomised, double masked, clinical trial of high dose vitamin A and vitamin E supplementation after photorefractive keratectomy. Br J Ophthalmol. 2001 May;85(5):537-9. Abstract; Page 537, Introduction, 1st paragraph; Page 538, Discussion, 1st paragraph; Page 538, 1st paragraph; Page 539, Conclusion 9 Shaw, H.B. Organotherapy or Treatment by Means of Preparations of Various Organs. London (UK): Cassell and Company Limited; 1905. 10 Shaw, H.B. Organotherapy or Treatment by Means of Preparations of Various Organs. London (UK): Cassell and Company Limited; 1905. 11 Shaw, H.B. Organotherapy or Treatment by Means of Preparations of Various Organs. London (UK): Cassell and Company Limited; 1905. 12 Shaw, H.B. Organotherapy or Treatment by Means of Preparations of Various Organs. London (UK): Cassell and Company Limited; 1905. 13 Harrower, H.R. Endocrine Diagnostic Charts. Glendale (CA): The Harrower Laboratory Incorporated; 1929. 14 Shaw, H.B. Organotherapy or Treatment by Means of Preparations of Various Organs. London (UK): Cassell and Company Limited; 1905.