Product Overview
Pharmax High DHA Finest Pure Fish Oil (with Essential Oil of Orange)- 5.1 fl oz (150 ml)
- • 1200 mg DHA and 260 mg EPA per serving size
- • Helps support cognitive health and/or brain function (1)
- • Helps support the development of the brain, eyes and nerves in children up to 12 years of age (2)
- • Sourced from tuna
- • NEO-3™ natural EPA and DHA enrichment
- • Convenient, great-tasting liquid format
- • Essential oils of orange and lemon flavor increases patient compliance
Additional product info:
EPA and DHA are crucial to brain development and normal brain functioning. The n-6 and n-3 series of long-chain polyunsaturated fatty acids (LC-PUFA) have an important role during gestation, lactation and infancy since they are constituents of cell membrane phospholipids and precursors of eicosanoids. LC-PUFA are biosynthesised from essential fatty acids (EFA) (linoleic acid, LA, 18: 2n-6, and linolenic acid, LNA, 18:3 n-3) by successive desaturation and elongation steps in the intestine, liver and brain. Both, arachidonic acid (AA, 20:4 n-6) and docosahexaenoic acid (DHA, 22:6 n-3), are found in neural structures and particularly DHA is a component of neurone membranes and external segments of photoreceptors in the retina (2). As such, fish oil supplementation rich in DHA such as tuna oil supports the development of the brain, eyes and nerves in children up to 12 years of age and helps support cognitive health and brain function (3).
DHA is particularly important to brain functioning due to its influence on neural membrane properties, which modulate cell signalling. DHA concentration in the brain decreases with age in humans and this has been postulated to be consequential to the age-related deterioration in central nervous system functions (4). Ninety days of DHA supplementation in the form of tuna oil (1,000 mg providing 252 mg DHA and 60 mg EPA) was found to significantly raise both plasma DHA and total ω-3 plasma, as well as significantly lower total ω-6 levels in participants aged 45-77 years. Moreover, for participants with corrected vision, the group receiving DHA (1,000 mg providing 252 mg DHA and 60 mg EPA) were found to have significantly better right eye visual acuity post-treatment in comparison with the placebo group (5).
References:
2 Gil A, Ramirez M, Gil M.Role of long-chain polyunsaturated fatty acids in infant nutrition.Eur J Clin Nutr. 2003 Sep;57 Suppl 1:S31-4. Page S31, Introduction;
3 NHPD Monograph on Fish Oil. March 2009.
4 Danthiir V, Burns NR, Nettelbeck T, Wilson C, Wittert G. The Older People, Omega-3, and Cognitive Health (EPOCH) trial design and methodology: A randomised, double-blind, controlled trial investigating the effect of long-chain omega-3 fatty acids on cognitive ageing and wellbeing in cognitively healthy older adults. Nutr J. 2011 Oct 20;10(1):117. Page 2, Background, 2nd paragraph
5 Stough C, Downey L, Silber B, Lloyd J, Kure C, Wesnes K, Camfield D. The effects of 90-day supplementation with the Omega-3 essential fatty acid docosahexaenoic acid (DHA) on cognitive function and visual acuity in a healthy aging population. Neurobiol Aging. 2011 Apr 30. Abstract; Page 2, 1st paragraph on right side
Other ingredients: Essential oil of orange, natural mixed tocopherols
