Product Overview
Pharmax Ultra EPA/DHA Liquid- 5.1 fl oz (150 ml)
Triglyceride form Includes high concentration of EPA and DHA. Yields 2920 mg EPA + DHA per teaspoon (5 ml) Almost 2:1 EPA:DHA ratio.1915mg EPA (Eicosapentaenoic Acid) and 1005 mg DHA (Docosahexaenoic Acid).
Independently tested Certified for proven quality, purity and label claims.
Great-tasting and fresh Great tasting natural orange flavor. Natural mixed tocopherols protects against oxidation; enhances product freshness and stability; and maintains a great clean taste throughout the entire shelf life of the product.
Cardiovascular and neurological support Each teaspoon (2920mg EPA = DHA) is utilized for the maintenance of good health,(1) maintains cardiovascular health(2) and helps support cognitive and brain function.(3) Also support the development of the brain, eyes and nerves in children up to 12 years old.(4) 2,800 – 3,000mg EPA + DHA per day containing a ration of EPA:DHA between 0.5:1 and 2:1, in conjunction with conventional therapy, helps to reduce the pain of rheumatoid arthritis in adults.(5)
References: 1-5. Health Canada. Natural Health Product Monograph - Fish Oil, 2009. [internet] [Accessed February 22, 2012]. Available at: http://www.hc-sc.gc.ca/dhp-mps/prodnatur/applications/licen-prod/monogra.... Additional product info: Fish oils may improve cardiovascular health by altering lipid metabolism, inducing haemodynamic changes, decreasing arrhythmias, modulating platelet function, improving endothelial function and inhibiting inflammatory pathways.(6) In fact, fish oil is recognized by the NHPD of Health Canada to help support and maintain cardiovascular health and to help reduce serum triglycerides/triacylglycerols.(7) Eicosapentaenoic acid (EPA; 22:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) are the 2 principal omega-3 fatty acids in marine oils. Recent data from human studies showed that these 2 fatty acids have differential effects on serum glucose (4 grams EPA), blood pressure (4 grams DHA), heart rate (4 grams DHA) and endothelial function.(8) EPA and DHA alter membrane fluidity, interact with transcription factors such as PPAR and sterol regulatory element binding protein, and are substrates for enzymes including cyclooxygenase, lipoxygenase and cytochrome P450.(9) Studies also show that EPA and DHA (1.6-2.0 grams EPA and 0.9-1.2 grams DHA) found in fish oils generate bioactive lipid mediators that reduce inflammation and polymorphonuclear leukocyte recruitment in numerous inflammatory disease models.(10, 11) While both EPA and DHA decrease TAG levels, only DHA appears to increase HDL and LDL particle size. Evidence to date also suggests that 2.8-4 grams DHA is more efficient in decreasing blood pressure, heart rate and platelet aggregation compared to EPA.(12) Thus, reduction of postprandial triacylglycerol (TG) concentration may be cardio-protective. Studies have shown that chronic omega-3 fatty acid supplementation (4 grams of either EPA or DHA) significantly lowers postprandial TG concentrations regardless of the type of fat in test meal.(13) EPA and DHA are also crucial to brain development and normal brain functioning. DHA is particularly important to brain functioning due to its influence on neural membrane properties, which modulate cell signalling. DHA concentration in the brain decreases with age in humans and this has been postulated to be consequential to the age-related deterioration in central nervous system functions.(14) As such, fish oil supplementation supports the development of the brain, eyes and nerves in children up to 12 years of age and helps support cognitive health and brain function.(15) References: 7, 15. Health Canada. Natural Health Product Monograph - Fish Oil, 2009. [internet] [Accessed February 22, 2012]. Available at: http://www.hc-sc.gc.ca/dhp-mps/prodnatur/applications/licen-prod/monogra.... 6, 9, 12. Cottin SC, Sanders TA, Hall WL. The differential effects of EPA and DHA on cardiovascular risk factors. Proc Nutr Soc. 2011 May;70(2):215-31. Abstract; Page 225 Conclusion 8. Woodman RJ, Mori TA, Burke V, Puddey IB, Watts GF, Beilin LJ.Effects of purified eicosapentaenoic and docosahexaenoicacids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension.Am J ClinNutr. 2002 Nov;76(5):1007-15. Page 1007, Introduction 10. McDaniel, J.C., Massey, K. and Nicolaou, A. Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds.Wound Repair Regen. 2011 Mar-Apr;19(2):189-200. Page 189, Abstract & Introduction 11. van der Meij, B.S., Langius, J.A., Smit, E.F., Spreeuwenberg, M.D., von Blomberg, B.M., Heijboer, A.C., Paul, M.A. and van Leeuwen, P.A. Oral nutritional supplements containing (n-3) polyunsaturated fatty acids affect the nutritional status of patients with stage III non-small cell lung cancer during multimodality treatment . J Nutr. 2010 Oct;140(10):1774-80. Page 1775, 2nd paragraph 13. Park, Y. and Harris, W.S. Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance.J Lipid Res. 2003 Mar;44(3):455-63. Page 455, Introduction 14. Danthiir V, Burns NR, Nettelbeck T, Wilson C, Wittert G. The Older People, Omega-3, and Cognitive Health (EPOCH) trial design and methodology: A randomised, double-blind, controlled trial investigating the effect of long-chain omega-3 fatty acids on cognitive ageing and wellbeing in cognitively healthy older adults. Nutr J. 2011 Oct 20;10(1):117. Page 2, Background, 2nd paragraph
Other ingredients: orange oil, natural mixed tocopherols
