Genestra Liquid Chlorophyll- 1 fl oz (30 ml)
• Chlorophyll formulation • 2.5 mg per drop • Ideal for vegans • Convenient liquid format increase patient compliance
Additional product info: Trimethylaminuria (TMAU) is a metabolic disorder characterized by the inability to oxidize and convert dietary-derived trimethylamine (TMA) to trimethylamine N-oxide (TMAO). This disorder has been relatively well-documented in European and North American populations, but no reports have appeared regarding patients in Japan. Yamazaki et al. identified seven Japanese individuals that showed a low metabolic capacity to convert TMA to its odorless metabolite, TMAO. The metabolic capacity, as defined by the concentration of TMAO excreted in the urine divided by TMA concentration plus TMAO concentration, in these seven individuals ranged from 70 to 90%. In contrast, there were no healthy controls examined with less than 95% of the metabolic capacity to convert TMA to TMAO. Subjects 1 and 2 were given 3 tablets (250 mg x 3) of activated charcoal, while subjects 1, 3 and 4 took copper chlorophyllin tablets for a total of 180 mg copper chlorophyllin per day. The intake of dietary charcoal reduced the urinary free TMA concentration and increased the concentration of TMAO to normal values during charcoal administration. Copper chlorophyllin was also effective at reducing free urinary TMA concentration and increasing TMAO to those of concentrations present in normal individuals. In the TMAU subjects examined, the effects of copper chlorophyllin appeared to last longer (i.e., several weeks) than those observed for activated charcoal. The results suggest that the daily intake of copper chlorophyllin may be of significant use in improving the quality of life of individuals suffering from TMAU (1).