Genestra Liver Support & Detoxification- 60 capsules
Product overview: Multi-herbal formula • Includes biotin, milk thistle, turmeric and licorice Ideal for vegans • Convenient vegetable capsule format
Additional product info: Milk thistle or its purified extract, silymarin (Silybum marianum), is widely used in treating acute or chronic hepatitis. A randomized, placebo-controlled trial in which participants, treating physicians and data management staff were blinded to treatment group was performed to determine whether silymarin improves symptoms, signs and laboratory test results in patients with acute clinical hepatitis, regardless of etiology. The intervention consisted of three times daily ingestion of either a standard recommended dose of 140 mg of silymarin or a vitamin placebo for four weeks with an additional four-week follow-up. The primary outcomes were symptoms and signs of acute hepatitis and results of liver function tests on days 2, 4 and 7 and weeks 2, 4, and 8. Patients receiving silymarin had earlier improvement in subjective and clinical markers of biliary excretion. The results suggest that standard recommended doses of silymarin are safe and may be potentially effective in improving symptoms of acute clinical hepatitis (1).
Eighty patients on hemodialysis were randomized into four groups to evaluate the effects of Silymarin and/or vitamin E on OS markers and hemoglobin levels in patients on hemodialysis. Group 1 received silymarin 140 mg 3 times daily; Group 2 received vitamin E 400 IU/day; Group 3 received silymarin 140 mg 3 times daily and vitamin E 400 IU/day; and Group 4 was the control. Oral supplementation with silymarinalone or in combination with vitamin E leads to reduction in malondialdehyde (MDA), increase in red blood cell (RBC) glutathione peroxidase (GPX), and increase in hemoglobin levels (2). 3-14.5 grams per day Milk thistle seed or 140-600 mg per day of Silymarin are used in Herbal Medicine to help support liver function, have been traditionally used in Herbal Medicine as hepatoprotectants and are used in Herbal Medicine to help relieve digestive disturbances and dyspepsia (3).
Turmeric rhizome at up to 9 grams per day provides antioxidants for the maintenance of good health and at 1-9 grams per day (3-5% curcumoids) is used in Herbal Medicine to aid digestion, to help relieve flatulent dyspepsia (carminative), as a hepatoprotectant, to increase bile excretion by the liver (choleretic) and stimulate contraction of the gallbladder (cholagogue) (4).
Licorice root and flower at 600-15,000 mg per day is used in Herbal Medicine to help relieve inflammatory conditions of the gastrointestinal tract, such as gastritis in adults, and traditionally used in Herbal Medicine as an expectorant to help relieve chest complaints, such as catarrhs, coughs and bronchitis (5).
References: 1 El-Kamary SS, Shardell MD, Abdel-Hamid M, Ismail S, El-Ateek M, Metwally M, Mikhail N, Hashem M, Mousa A, Aboul-Fotouh A, El-Kassas M, Esmat G, Strickland GT. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis. Phytomedicine. 2009 May;16(5):391-400. 2 Roozbeh J, Shahriyari B, Akmali M, Vessal G, Pakfetrat M, Raees Jalali GA, Afshariani R, Hasheminasab M, Ghahramani N. Comparative effects of silymarin and vitamin E supplementation on oxidative stress markers, and hemoglobin levels among patients on hemodialysis. Ren Fail. 2011;33(2):118-23. 3 NHPD Monograph on Milk Thistle. June 2009. 4 NHPD Monograph on Turmeric. February 2010. 5 NHPD Monograph on Licorice. February 2008.
Other ingredients: Hypromellose, silica, vegetable magnesium stearate